Is melatonin safe to take during pregnancy?

What we know so far (and what we do not)

Melatonin is a hormone your brain makes naturally, and it also plays a role in pregnancy and fetal development.

When taken as a supplement, melatonin can cross the placenta, which means the fetus is likely exposed. That is not automatically harmful, but it is one reason clinicians tend to be cautious with routine use.

A 2021 review in the medical literature concluded that evidence from clinical studies to date suggests melatonin use during pregnancy and breastfeeding is probably safe in humans (T Vine, 2021, pmc.ncbi.nlm.nih.gov). A 2022 review similarly reported that melatonin was shown to be safe to take in pregnancy in available studies, while noting it has not looked especially promising as a preventative therapy for certain complications (R Verteramo, 2022, pmc.ncbi.nlm.nih.gov).

Still, “probably safe” is not the same as “proven safe for everyone.” Many studies are small, focus on specific medical situations, or do not track children for years. For everyday insomnia in otherwise uncomplicated pregnancies, many clinicians prefer to start with non medication approaches first.

When melatonin may be a reasonable discussion with your OB team

Sleep can fall apart during pregnancy, especially in the first and third trimesters.

Melatonin is sometimes considered when insomnia is persistent and affecting daytime function, and when behavioral changes have not helped enough. It may also come up if you have shift work sleep disruption or significant circadian rhythm changes.

The key is that “safe” depends on context, including your pregnancy history, other health conditions, and what else you are taking. Your clinician can help weigh the potential benefits against the unknowns, and suggest alternatives that have more pregnancy specific safety experience.

Pro Tip: Before adding any sleep aid, ask whether your sleep problem is being driven by reflux, restless legs, anxiety, or frequent urination. Treating the cause often improves sleep more than any supplement.

Who should be extra cautious or avoid self-treating

Even though the published reviews are reassuring overall, certain situations deserve a more careful plan.

Important: Do not use melatonin as a substitute for urgent evaluation if you have severe anxiety, depression, or symptoms of sleep apnea (loud snoring, choking or gasping at night, or significant daytime sleepiness). Those conditions can affect pregnancy outcomes and need targeted care.

Dose, timing, and product quality, the practical safety issues

There is no universally agreed “pregnancy dose” for melatonin. Many over the counter products contain far more melatonin than the body naturally produces at night, and supplement labels are not always reliable.

If your clinician agrees melatonin is appropriate, ask about the lowest effective dose and the shortest duration that meets your goal. Taking more is not necessarily better, and higher doses may increase side effects like vivid dreams, morning grogginess, headache, or nausea.

Timing matters, too. Melatonin is a “darkness signal” to the brain, so it is usually taken in the evening rather than in the middle of the night. Poor timing can worsen circadian misalignment and may disrupt normal sleep stages, including REM sleep.

Finally, choose products that have third party quality testing when possible. This reduces (but does not eliminate) the risk of mislabeled dose or contamination.

Safer first steps for pregnancy insomnia

For many pregnant people, non drug strategies meaningfully improve sleep within 1 to 2 weeks.

If insomnia is severe, ask your obstetric clinician about pregnancy appropriate options and whether screening for anemia, thyroid disease, mood disorders, or sleep apnea makes sense.

When to stop melatonin and contact a clinician

Stop the supplement and seek medical advice if you notice symptoms that feel out of proportion or unsafe.

The overall research picture is reassuring, but individualized decision making is still the safest approach. The best plan is the one that improves sleep without adding avoidable risk.

What the research shows: Reviews of human studies have found melatonin in pregnancy is probably safe overall, but they also emphasize that data are limited and that more research is needed on optimal dosing and long term child outcomes (T Vine, 2021, pmc.ncbi.nlm.nih.gov; R Verteramo, 2022, pmc.ncbi.nlm.nih.gov).